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Individual differences in latent
inhibition: behavioral correlates with partial reinforcement
extinction effect and signal detection Elias Tsakanikos and Phil Reed University College London, United Kingdom This study tested forty rats in several appetitive conditioning paradigms to investigate the within and between subjects variation in performance in three behavioural tasks: latent inhibition (LI), the partial reinforcement extinction effect (PREE), and signal detection (SD). It was hypothesized that, if LI is indeed a reliable animal model of schizophrenia, low LI scorers also would demonstrate higher response biases in the SD task than the high LI scorers. Moreover, there would be no difference in sensory sensitivity. Additionally, since both LI and PREE effect follow a similar pattern after the same psychopharmacological interventions (i.e. disruption after amphetamine, and enhancement after haloperidol administration) it was hypothesized that possible behavioural correlates between LI and PREE would open a theoretical dialogue on the functional links between the two effects. Keywords: Individual differences, schizophrenia, latent inhibition, partial reinforcement extinction effect, rats |
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