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Interactions between galanin
and morphine in mice. Mónika Mácsai, Annamária Kaszás, Gyula Telegdy and Gyula Szabó University of Szeged, Albert Szent-Györgyi Medical and Pharmaceutical Center, Szeged, Hungary Galanin is expressed in the central and peripheral nervous system where acts as a neurotransmitter/neuromodulator. Galanin-like immunoreactivity and receptors are found in dorsal root ganglion cells and in dorsal horn interneurons, suggesting that this neuropeptide may have a role in sensory transmission. We tested the effects of the peptide treatment given intracerebroventricularly on pain sensitivity, morphine analgesia and on tolerance to and dependence on chronic morphine administration. Heat-radiant tail-flick method was used to assess the nociceptive threshold in CFLP mice. Galanin given intracerebroventricularly itself had an analgesic effect, and it increased the analgesic effect of morphine. Galanin significantly increased the chronic tolerance to morphine. Galanin has an analgesic effect, and also interacts with acute and chronic effects of morphine. Keywords: galanin, pain, opiate, mouse |
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