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Synthèse et fonctionnalisation d’oligosaccharides sulfatés
Nous obtenons des oligosaccharides anioniques, en particulier sulfatés, par différents voies : la synthèse chimique, la modification d’oligosaccharides naturels, et la dégradation contrôlée des polysaccharides. Nous développons les outils nécessaires à leur fractionnement, purification et l’analyse (HPAEC, ESI-MQS, MALDI).
Tensioactifs pour la flottation des métaux
La contamination des sols et des eaux par les métaux causant à la fois de graves problèmes d’environnement et de santé publique, il est nécessaire de traiter les zones contaminées. Parmi les nombreux procédés de dépollution existants, nous nous sommes intéressés à la flottation. Nous avons synthétisé tout un panel de tensioactifs à base de glucose, comportant une chaîne hydrocarbonée et une fonction complexante.
Ligands Multivalents
Nous avons développé une méthodologie de synthèse pour la fonctionnalisation de saccharides qui vont nous servir de charpente pour l’obtention des ligands multivalents. Cette méthodologie nous à permit d’obtenir un panel de charpentes oligosaccharidiques portant des azotures sur lesquelles nous avons ensuite « clické » des éléments de reconnaissance. Nous avons également étudié l’effet de la multivalence sur les inhibiteurs de glycosidases et obtenu des ligands multivalents de haute affinité pour les galectines.
Comparative analysis of sulfated and sulfonated disaccharide analogs as TLR4 modulators and heparanase inhibitors |
Characterization of carboxylated cellulose nanofibrils and oligosaccharides from Kraft pulp fibers and their potential elicitor effect on the gene expression of Capsicum annuum |
Octanoyl esterification of low molecular weight sulfated galactan enhances the cellular uptake and collagen expression in fibroblast cells |
DP2, a Carbohydrate Derivative, Enhances In Vitro Osteoblast Mineralisation |
Sulfated Galactans from Gracilaria fisheri with Supplementation of Octanoyl Promote Wound Healing Activity In Vitro and In Vivo |
Using NMR to Dissect the Chemical Space and O-Sulfation Effects within the O- and S-Glycoside Analogues of Heparan Sulfate |
Synthesis of novel S- and O-disaccharide analogs of heparan sulfate for heparanase inhibition |
Ring-Opening of Cyclodextrins: An Efficient Route to Pure Maltohexa-, Hepta-, and Octaoses |
Effects of CoCl2 on the regioselective tosylation of oligosaccharides |
One-Pot Synthesis of Asymmetrically Difunctionalized Oligomaltosides by Cyclodextrin Ring Opening |
Synthesis of new sulfated disaccharides for the modulation of TLR4-dependent inflammation |
A simple procedure to obtain a medium-size oligogalacturonic acids fraction from orange peel and apple pomace wastes |
Synthesis of defined oligohyaluronates-decorated liposomes and interaction with lung cancer cells |
Production of Oligosaccharides from Agrofood Wastes |
Uncommon Strong Inhibition of α-Glucosidase by Multivalent Glycoclusters built on Cyclodextrins Scaffolds |
Synthesis of multivalent S-glycosides analogs of a heparan sulfate sequence |
High resolution MALDI-TOF-MS and MS/MS: Application for the structural characterization of sulfated oligosaccharides |
Solid-phase synthesis of molecularly imprinted polymer nanolabels: Affinity tools for cellular bioimaging of glycans |
Biological impact of octyl D-glucopyranoside based surfactants |
Synthesis and Insecticidal Activities of Novel Solanidine Derivatives |
Kinetics of the incorporation of the main phenolic compounds into the lignan macromolecule during flaxseed development |
La chimie en Région Hauts-de-France : Chimie de la biomasse |
Applications of Glycosaminoglycans in the Medical, Veterinary, Pharmaceutical, and Cosmetic Fields |
Oligogalacturonic Acid Inhibits Vascular Calcification by Two Mechanisms: Inhibition of Vascular Smooth Muscle Cell Osteogenic Conversion and Interaction With Collagen |
Chirality inversion, supramolecular hydrogelation and lectin binding of two thiolactose amphiphiles constructed on a di-lauroyl-l-tartaric acid scaffold |
Glycochemical Applications of Diels-Alder Reaction |
Chapter 5 Recent Advances in the Synthesis of Sugar-based Surfactants |
Multivalent sialylation of β-thio-glycoclusters by Trypanosoma cruzi trans sialidase and analysis by high performance anion exchange chromatography |
Octyl glucoside derivatives: A tool against metal pollutants |
Cholesteryl and diosgenyl glycosteroids: synthesis and characterization of new smectic liquid crystals |
Development of an NMR metabolomics-based tool for selection of flaxseed varieties |
Chapter 11 Anionic oligosaccharides: synthesis and applications |
Synthesis of divalent ligands of β-thio-and β-N-galactopyranosides and related lactosides and their evaluation as substrates and inhibitors of Trypanosoma cruzi trans-sialidase |
Design and Synthesis of Hydrolytically Stable Multivalent Ligands Bearing Thiodigalactoside Analogues for Peanut Lectin and Human Galectin-3 Binding |